Russian biologists have successfully tested the operation of the drug to slow cell aging in mice, prolonging their life by 15%, or 45 days, and published the results of experiments in the journal Aging.
“This work is important from both a theoretical and a practical standpoint. On the one hand, it shows the key role of reactive oxygen species produced by the mitochondria in mammalian aging. On the other hand, opens the way to treat aging antioxidants, specifically aimed at the mitochondria, “- explains Vladimir Skulachev Academician, Dean of the Faculty of Bioengineering and Bioinformatics, Moscow State University.
As previously told Skulachev, he is a supporter of the theory of August Weismann. She postulates that death and aging is not random processes of decay tissues of the body and dying cells, and targeted program that causes evolutionary older organisms to give way to new generations of living beings.
Following this idea, academician and his scientific team for several years working to develop drugs that could slow down the aging of one of the most important parts of cells – their mitochondria, the original “power plants” of our body. The mitochondria occurs nutrient oxidation and conversion of their energy into ” Energo currency” cells, ATP molecules necessary to run all processes requiring energy expenditure.
Skulachev’s team several years ago opened molecule SkQ1 introduction that can solve this problem. It is a powerful antioxidant that can penetrate the mitochondria and neutralize the aggressive oxidizing molecules, destroying its walls and reduce its efficiency. This material is part of the eye drops “Vizomitin” which Skulachev and his colleagues delivered for several years in Russian pharmacies.
In the new work, published in a peer-reviewed scientific journal, and his fellow Skulachev showed that SkQ1 introduction really slows aging by helping mitochondria last longer and work better.
Its scientists have conducted experiments on a special line of mice genetically predisposed to occurrence of random mutations in the DNA of mitochondria. Such mice live an extremely short-lived compared to conventional laboratory rodents is approximately 280-290 days instead of 2-3 years. The accumulation of mutations and the destruction of the mitochondria resulted in massive loss of cells, premature aging and death.
Having these mice, the researchers divided them into two groups, one fed a normal diet, and the second – a diet supplemented with SkQ1. When the rodents reached an eight-month of age, the differences between the representatives of both groups became visible even an uninformed observers.
For example, the mouse from the control group began to rapidly lose weight, they have to bend the spine, they lose hair and generally began to behave like a mature individual. On the other hand, rodents, collisions, do not exhibit typical SkQ1 introduction the signs of aging at least 40-45 days, making them a healthy old age lasted much longer than the first. On average, mouse, collisions, SkQ1 introduction lived about 335 days, while individuals in the control group were usually only up to 290 days.
In addition to “Vizomitin” Skulachev and his team are working on and the start of production of other medications on the basis of SkQ1, oral solution. He is now, according to the press service of the Moscow State University, in clinical studies. If successful, these studies “a cure for old age” may appear in the pharmacies through 2-3 years.
Original: RIA Novosti